An experiment found that the brain uses one set of neural circuits to identify the numbers 1–4; these circuits are very specific to their own numbers. A separate set of circuits respond to the numbers 5–9; these are less precise, and are activated by adjacent numbers....
Defining #neural#modularity is hard: much history. We used toy ANNs to show structural and functional definitions not tightly related, resource constraints important, and we need to start thinking about temporal dynamics.
What are some things you’ve always wondered about hippocampal #Replay? ⚡🧠
They can be simple questions (like: “what’s the longest replay you’ve ever seen?”) or more complex (like: “does replay = thought?”).
Fire away! You might get an answer (not necessarily from me: anyone can answer!)
Now that I'm moved to neuromatch.social, a new #introduction.
I’m a professor at UPenn who studies memory. I work at the nexus of brain research and computation. I’m also writing a book: When it comes to understanding the brain, what are we trying to achieve? What’s our plan to get there? What challenges do we face?
Writing has deepened my appreciation for community-based progress. I'm excited to be here to participate in, and benefit from, collective intelligence.
I'm also committed to restraining myself from the power of 10K characters. But I will Edit - that is the superpower that we all deserve.
I'd love to chat with a #vision scientist about why they think some things have a "right side up" and not others. writing is strongly orientation sensitive, but brain doesn't seem to care when recognizing and processing lots of other complex objects. seems like a weird gap in my understanding and a really basic question. #neuroscience#neuro@neuro@neuroscience
Hello fellow scientists, I'm looking for academic journal suggestions!
Where would you submit, or where would you go read a paper about clustering subjects based on the similarity network built from their cognitive and motor tests scores after stroke?
Preprint at https://www.medrxiv.org/content/10.1101/2023.11.08.23297808v1
The paper discusses both methodology (similarity measures*, graph clustering**, compared to the tradition in the field of PCA and regression), and clinical aspects (typical lesions of cluster, diagnostic power of the assessment).
It is too computerish for some clinical neurology journal, not enough for some computers-in-med/bio/etc journal.
Must be #openaccess
Ofc it's a team decision, won't be based on replies, but I am an early stage researcher and I really value discussions outside my lab!
*it's an old, little known one!
**it may be argued one of the techniques is new, both seem new wrt stroke
If you want to modify parts of a chronic implant for #neuroscience , imaging / ephys / etc. do you use Solidworks or Autodesk Fusion 360 or Autodesk Inventor. Going to invest in intellectual capital (aka learn new software) locally for novel designs and want to make a good initial choice. Would love to hear from @Daharoni as different choices appear in your different projects.
Just saw a new article in “Applied Sciences”, a MDPI journal and I would like to advise everyone not to publish there… the paper is full of inaccurate statements and I’ve heard that MDPI was kind of predatory. Happy to hear any contradictory opinion though. #ScientificPublishing#Neuroscience#AppliedSciences#MDPI
Before epilepsy was understood to be a neurological condition, people believed it was caused by the moon, or by phlegm in the brain. They condemned seizures as evidence of witchcraft or demonic possession, and killed or castrated sufferers to prevent them from passing tainted blood to a new generation.
The gist here is to model a genetic network as a dynamical system with two attractor states (in this case, it's leukemia and the states are apoptosis on-versus-off).
I'm looking for leads to papers that apply this type of approach to model genetic networks (not neural circuits) that have something a bit more to do with the brain; ideally not cancer.
(This is not my field). Huntington's? Fragile X? Anything neuron related?
Brenner, without skipping a beat, stated this served his purposes just fine: to study variability in synaptic connectivity among otherwise isogenic animals – and found lots, enough to state that genetic determinism w.r.t. neural circuit configuration as understood at the time was largely hogwash.
"Frame on neuron 393766777 from the Janelia hemibrain. Orbit the camera 45 degrees over 6 seconds, and move in 25% while orbiting. 1 second in, fade on neuron 1196854070 over 1 second. Then fade on the output synapses of 393766777 connecting to 1196854070 taking 1 second. Synapses should be extra big."
I'm teaching a class in Neuroecology for first year PhD students and part of it is a journal club.
I'm looking for additional, pure behavior papers that study "natural" / ecological behaviors, if possible not in mice.
And also for rather short papers that perform any form of brain recordings during natural /ecological behaviors (plus points if not in mice).
Merck announces plans for a new research centre in London next to The Crick, while asking, together with other pharmaceutical companies for deregulation, higher costs for medicines, and lower taxes: https://www.ft.com/content/b0bbed9a-aaf7-4f95-8d59-96548c9c9a25
“We need to invest in neuroscience because there’s a screaming need for it”, sounds great, I hope this means fundamental basic research, because it’s nigh impossible, or plain chance, to fix something one doesn’t know how it works.
If MINI2P is good and open-source and reasonable cost-wise.. what reason would anyone have for pursuing 1P GRIN lens miniscope imaging any further? Any thoughts?
I haven't dug much further yet but my main hesitance would be just that I haven't seen it set up and used in labs outside of the developers' yet. Often there are implicit tricks and expertise that turn out to be important when transferring a technique.
Can we control an entire distributed circuit in the brain? If not now, when?
Neurotechniques can do amazing things. One can target a population in region A to track specific projections to region B, and then study the impact on B.
How far beyond that can we already go? What is the most extreme example that you know of open- or closed-loop manipulation?
Your brain finds it easy to size up four objects but not five — here’s why (www.nature.com)
An experiment found that the brain uses one set of neural circuits to identify the numbers 1–4; these circuits are very specific to their own numbers. A separate set of circuits respond to the numbers 5–9; these are less precise, and are activated by adjacent numbers....
Scientist, after decades of study, concludes: We don't have free will (phys.org)
Before epilepsy was understood to be a neurological condition, people believed it was caused by the moon, or by phlegm in the brain. They condemned seizures as evidence of witchcraft or demonic possession, and killed or castrated sufferers to prevent them from passing tainted blood to a new generation.