Not a placebo-controlled trial, just an open-label study
“67% reported improvement in the low-dose naltrexone group compared with 61% taking amitriptyline and 41% receiving physical therapy alone. Patients taking duloxetine only reported improvement in 35%”
“in this cohort, there was a significant risk participants under-reported, rather than over-reported, cognitive difficulty that was detected on NP [neuropsychological] testing”
Update I saw today from somebody in the #MECFS community. Please highlight widely.
"I inquired about the trial a couple of weeks ago, one of the coordinators mentioned that they only had 11 people participate so far, their goal is to recruit roughly 100. The location is very easy to get to via public transit, the trial location is set on the Upper East Side (a few blocks away from the 96th St. subway station). If you are in the New York Metro Area, please consider participating."
“Our analysis suggested an improper crosstalk between the cellular and humoral adaptive immunity in #LC, which can lead to immune dysregulation, inflammation and clinical symptoms associated with this debilitating condition”
An essay inspired by Giorgia Lupi's recent high profile article in the NY Times, also detailing the author's experiences. "It is September, 2022, the beginning of the waiting rooms. I'm glad I don't know what's coming. The very first doctor that I see says the pain I feel is anxiety”
I’ve been trying to figure out how to describe brain fog to those who have not experienced it, using things they might have felt. The closest I can get is:
It’s like being high on cannabis without the pleasurable part.
It’s like being hungover without having had any alcohol.
It’s like the way you would feel after pulling two all-nighters in a row and not drinking any coffee.
It feels like you have traumatic brain injury (“concussion”) but from the inside out.
Anyone else have any foggy thoughts?
I’m crashing today after having to over-exert myself this weekend and last night with snow removal and the fog is thick today.