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steveroyle, to random
@steveroyle@biologists.social avatar

Vaults are the most mysterious things inside the cell. This profile of Leonard Rome - the Vault Guy - is fascinating.

https://www.science.org/content/article/biologist-aims-solve-cell-s-biggest-mystery-could-it-help-cancer-patients-too

steveroyle, to random
@steveroyle@biologists.social avatar

The Lysosomes and Endocytosis GRC looks great this year. Sadly I'm not going 🙁

https://www.grc.org/lysosomes-and-endocytosis-conference/2024/

steveroyle,
@steveroyle@biologists.social avatar

@kofanchen so true. Expensive: carbon, money and… time!

albertcardona,
@albertcardona@mathstodon.xyz avatar

@steveroyle @kofanchen

If the UK higher Ed institutions supported train travel: carbon footprint is much lower, time isn't wasted around hallways and staircases and entirely unnecessary queues. If only. But they don't because direct costs to them are higher than flying.

steveroyle, to random
@steveroyle@biologists.social avatar

This is terrible news about Andrew Fry. He was a rigorous scientist and a very generous person. We collaborated on a fantastic paper led by Laura O’Regan in his lab on Hsp72. Although this is the only paper we're co-authors on, we had many joint meetings and discussions with his group and the Bayliss lab.

steveroyle, to accessibility
@steveroyle@biologists.social avatar

How can we improve for scientific conferences? This short guide by Ulla McClurg covers many of the issues that organisers (and attendees) can consider.

https://journals.biologists.com/jcs/article/137/10/jcs261858/352179/A-short-guide-to-addressing-accessibility-at

steveroyle, to random
@steveroyle@biologists.social avatar

What's the rule? Three crashes of Word and it's time to go home? I'm on two.

steveroyle,
@steveroyle@biologists.social avatar

@albertcardona hey my go to sadism is TeX. MSWord is inflicted on me in this case by a funding agency. 😃

albertcardona,
@albertcardona@mathstodon.xyz avatar

@steveroyle

In such cases, I write latex or markdown and then pandoc to DOCX, then copy-paste into the funding agency's tabulated template.

Because actual writing in MSWord is infuriating, particularly when aggravated by a straightjacket template that keeps complaining and moving text around.

steveroyle, to random
@steveroyle@biologists.social avatar

Interesting read on "Finding my leadership style" by Helen Walden. A personal reflection on being a PI, a Head of School with a side order of doing so as a woman.

Sorry, it's paywalled (and I have to say very difficult to access even with a subscription) but I enjoyed reading it.

#LabLife #LifeOfPI

https://doi.org/10.1016/j.chembiol.2024.04.010

steveroyle, to random
@steveroyle@biologists.social avatar

Google offers “web search” option without all the AI gunk. Idea: they could maybe make this default?

https://www.theverge.com/2024/5/14/24074314/google-now-offers-web-search

steveroyle, to random
@steveroyle@biologists.social avatar

It seems I have found a new way to procrastinate on a grant application. Using to make my Gantt chart!

steveroyle,
@steveroyle@biologists.social avatar

@albertcardona I agree with you. Although in this case, I feel it is helping me to plan. The person needs to work at another lab for part of the project. That would be best to tie in with the academic year for housing reasons. That affects when one aim is completed by, which means another aim needs starting later etc etc.

I know the Mike Tyson quote before you say it :-)

albertcardona,
@albertcardona@mathstodon.xyz avatar

@steveroyle

😀 Plans and meeting the enemy and all that.

steveroyle, to random
@steveroyle@biologists.social avatar

This is cool. Wade Harper’s lab are experimenting with publishing direct to their lab website.
https://harperlab.pubpub.org

There is one pub up at the moment which is also on bioRxiv
https://harperlab.pubpub.org/pub/nlrp3/release/1

An editor has been assigned and it looks like peer review will be totally open.

The first author Robert Hollingsworth has written a thread on the bad place about his motivations behind this expt (seek it out if you're interested!)

jonny,
@jonny@neuromatch.social avatar

@steveroyle
Me seeing this and doing the jack Nicholson "good" nod
https://neuromatch.social/@jonny/112291367865492639

steveroyle, to random
@steveroyle@biologists.social avatar

This preprint on native synaptic vesicles structure comes hot on the heals of related work from others.

The images are so cool. Clathrin coated vesicles in synapses are only partially coated.

http://biorxiv.org/cgi/content/short/2024.04.11.588828v1

#cellbiology

steveroyle, to Espresso
@steveroyle@biologists.social avatar

Having just serviced and replaced seals on a La Pavoni machine using nothing but tools and bike grease, I am wondering if I now qualify for Italian citizenship.

steveroyle, to microscopy
@steveroyle@biologists.social avatar

Preprint describing Nellie, a napari plugin for automated organelle segmentation. Results look impressive!

https://arxiv.org/abs/2403.13214

repo (with video): https://github.com/aelefebv/nellie

#CellBiology #microscopy #napari

steveroyle, to random
@steveroyle@biologists.social avatar

Wow, this looks exciting!

“Atomically accurate de novo design of single-domain antibodies”

from the Baker lab (of course)

https://www.biorxiv.org/content/10.1101/2024.03.14.585103v1

#RFdiffusion #proteinDesign #cellBiology

steveroyle,
@steveroyle@biologists.social avatar

Nature News covers the antibody design preprint.

I'll mischievously suggest that this is what Nature as a bioRxiv overlay journal could look like.

https://www.nature.com/articles/d41586-024-00846-7
#RFdiffusion #proteinDesign #cellBiology

steveroyle, to random
@steveroyle@biologists.social avatar

My calendar for tomorrow shows a quadruple booking. Only a triple booking today.

steveroyle,
@steveroyle@biologists.social avatar

aaaand just received an invite to “Prioritising Your Workload and Knowing When to Say No”, a workshop which runs from 1000-1600.

albertcardona,
@albertcardona@mathstodon.xyz avatar

@steveroyle

This is self-parody. At least you got a good laugh.

steveroyle, to random
@steveroyle@biologists.social avatar

Post by Markus Meister about @eLife ’s publishing model. Positive assessment and a plea to make “live” preprints & abandon typesetting.

https://markusmeister.com/2024/03/17/a-year-into-elifes-new-publishing-model/

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