Happy #FossilFriday, these are the broken lower leg bones (fibulae) of the tyrannosaurs Teratophoneus and Lythronax! Partial healing has occurred in both specimens, indicating the animals lived with the breaks for a short time before dying. (1/2) #paleontology#pathology#paleopathology#dinosaur#science
Was NOT expecting to get a new PATHOLOGY album this year but we are! Their next full length 'Unholy Descent' is out May 17, and this is the first single from it, "Cult of the Black Triangle".
Pathology is one of the heaviest, most intense bands around, and I'm psyched to hear the rest of this record.
"New York Supreme Court Justice Arthur Engoron’s 92-page ruling fining Donald Trump approximately $364 million includes the jurist’s scathing observations about Trump and his executives’ practices.
In an almost literary section of his ruling titled, 'Refusal to Admit Error,' Justice Engoron writes, 'Their complete lack of contrition and remorse borders on pathological.'”
I've listened to a bunch of stuff today, some good, some meh. A GREAT one that maybe shouldn't have surprised me is this Pathology record 'The Everlasting Plague' from 2021 that I'm just hearing today for the first time fully.
It is SO good. Some both brutal and very MELODIC stuff here. A few cool intros and solos, and those are pretty rare in metal, a lot of times - especially in the heavier stuff.
Join Mayo Clinic & an elite roster of speakers for Surgical Pathology Updates 2024. The course covers a range of subjects in diagnostic pathology for the general surgical pathologist. Feb. 14-17 in Arizona & via livestream – register today. https://tinyurl.com/27f9aaxw
Do respiratory diseases like #COVID increase the spread of other diseases? Just reading about latent tuberculosis, and wondering if it can be spread by another disease's symptoms. #longcovid#bio#pathology
Off to the pathology museum this morning to do a bit more work with the tooth collection and to try to organise research on a particularly well documented and strange case of phossy jaw. #anatomy#pathology
New preprint alert
"Pathway-specific progression of Tau pathology in the human thalamus"
We discovered that large presynaptic terminals containing vGLUT2 preferentially accumulate paired helical filaments of #Tau in the anterodorsal nucleus of the #thalamus, even at the stage before #Alzheimer’s disease.
But we could not detect them in the small corticothalamic terminals, suggesting Tau is not spreading anterogradely from the #cortex.
We also detected pathological Tau in both presynaptic and postsynaptic sites, which suggests Tau crosses specific #synapses.
Adjacent thalamic nuclei such as the anteroventral and mediodorsal were relatively resistant to Tau #pathology.
We suggest there is a 'hidden' #subcortical route for the spread of Tau in the ageing human #brain.
Since the anterodorsal thalamic nucleus is so vulnerable, and contains high densities of #neurons that are sensitive to head direction and gravity, it may explain the very early deficits in spatial orientation in people that go on to develop Alzheimer’s disease.
Please see our #preprint for further details: https://www.biorxiv.org/content/10.1101/2023.06.05.543738v1
The discussion after the talk at #ConsPath1 concentrated on the notions of #pathology and #malfunction, and on the way in which testimonial practises work in delusions and conspiracy beliefs.
A white supremacist took MDMA for a study, and it snapped him out of his beliefs: 'Why am I doing this?' (www.insider.com)
30 minutes after taking the MDMA pill, Brendan questioned his actions and realized his life was missing connection.