Neuroscience

weberam2,
@weberam2@qoto.org avatar

What are some #nonprofit #openaccess journals that specialize in #neuroimaging #neuroscience and/or #pediatrics?

Hein_Lab,
@Hein_Lab@neuromatch.social avatar

🎉Exciting opportunity! 13 PhD positions open in our RTG 2660 on approach and avoidance behaviour!

@uni_wue @RTG2660

_ohcoco_, (edited )
@_ohcoco_@mastodon.social avatar

From one of my texts for class >>>

We take so many of these statements at face value because they seem to make sense in our system, and then before we know it we’ve got terrible, repressive, socially-accepted "knowledge."





(text title in )

iANikzad,
@iANikzad@neuromatch.social avatar

A Thousand Brains : a new theory of intelligence

Hi :)
I'm a new member of this amazing community and I would like to have my first post on the amazing breakthrough of Jeff Hawkins.

Before giving my opinion, I would like everyone to tell me whether they know the theory of have they read the book or the original papers and If so what's their insight on them?

I think the material in this research is pretty much fascinating and would like to engage and talk about it more.


jonny,
@jonny@neuromatch.social avatar

@iANikzad
Am not aware of the work! What is it? And welcome!!

iANikzad,
@iANikzad@neuromatch.social avatar

@jonny well it's a long story and I plan to tell the story here bit by bit and exchange opinions

You can check out the book "A Thousand Brains: a new theory of intelligence" by Jeff Hawkins as I mentioned earlier which he gradually introduces the concept himself, the book is made to be convenient to read and easy to understand.

But in a nutshell here is what you will be seeing in this theory(it got a bit long sorry in advance, it's worth it though=) :

Long ago in 1970s Professor Mountcastle introduced the idea of "cortical columns". He proposed that essentially different parts of our brain is doing the same thing and their building block is "cortical column"s. This idea itself has many biological evidence backing it from the idea of evolution copying what has works throughout the brain based on huge increase in our cortex (or to be more accurate "Neocortex") in the last 2 or 3 million years which is nothing compared to the age of evolution. and examination of same pattern of each slice of our brain even with different responsibilities and so on...

So mountcasle Knew that all this diversity of intelligence is in our brain and these cortical columns but didn't know what the algorithm was.

As Hawkins says, It reminds of the Darwin Theory of evolution. Darwin suggested that there is an algorithm for diversity of life and Mountcastle suggests there is one for diversity of Intelligence.

The interesting difference is that Darwin knew "what" the algorithm is but didn't know "where" it was in our body.
Mountcastle didn't know "what" the algorithm is but he knew "where" in the body it is.

Jeff Hawkins new theory of Intelligence unravels what might this "algorithm" be.

It's fascinating isn't it? :)
And to make you more excited, after understanding the idea of this new theory, it walks you through how "understanding language", "vision" or even "touch" are essentially the same

#Neuroscience
#new_theory_of_intelligence
#Jeff_Hawkins

albertcardona, Catalan
@albertcardona@mathstodon.xyz avatar

“A Connectome of the Male Drosophila Ventral Nerve Cord”, by Takemura et al. 2024

https://elifesciences.org/reviewed-preprints/97769

brembs,
@brembs@mastodon.social avatar

How cool is this?
Tethering transgenic fruit flies to a torque meter inside of a 360° display to let them learn how to control a punishing heat beam with their turning attempts.
It looks like we have finally discovered in which neurons the plasticity takes place that is required for this kind of learning:

https://f1000research.com/articles/13-116

We may not be 100% sure, yet, but everything is pointing towards plasticity in the motor neurons of the ventral nerve cord that control the wing angles.

jonny,
@jonny@neuromatch.social avatar

@brembs
The idea of short term learning in motor neurons in a ganglionic nervous system is giving me chills and I cant quite pick out why. Embodied learning where there isnt a clear distinction between "symbolic" learning of "how to control beam" as some thought abstracted from its physical reality as a motor pattern is beautiful to me, even if I am oversimplifying/misunderstanding bc I know next to nothing about fly brains and this long research question

susanleemburg,
@susanleemburg@neuromatch.social avatar

O man... I thought that the OpenEphys ONIX system was just a new kind of headstage that works with most of their old hardware.

Does anyone have an ONIX? Is it worth it for just multichannel LFP or tetrode recordings?
#neuroscience #neuromastodon

susanleemburg,
@susanleemburg@neuromatch.social avatar

Alternatively, a wireless system that can do ~2kHz sampling rate and doesn't have a pathetic little battery life of 2 hours would be great too.

jonny,
@jonny@neuromatch.social avatar

@susanleemburg
We are working on a wirelessly powered thing but I have no idea when its projected to be released :'(

biogeo,
@biogeo@mathstodon.xyz avatar

Neuroscientists and electrophysiologists of Mastodon, what would your top choice analysis tool be for a novice getting started with working with ECoG data? I have a graduate student I will be co-mentoring starting this Fall who is very bright but has no programming experience, and I'd like to help her get up and running as quickly as possible. I've generally been a roll-my-own-analyses type of electrophysiologist so I don't have a favorite framework to get her started with. I know EEGLAB is popular, but my main experience with it has been helping other people get their Matlab path working properly again after something in EEGLAB clobbers it. I've played with MNE in Python but it doesn't seem to be as purely-GUI as EEGLAB and I don't want her to get bogged down in learning Python before she can do any analyses at all.

So, what's your favorite tool for ECoG analysis? What would you recommend a student who's starting from zero background in electrophysiology or programming begin to learn in 2024?

Boosts for reach appreciated. I also just like hearing folks' opinionated takes on their research tools.

moritz_negwer,
@moritz_negwer@mstdn.science avatar

Clever neuronal activity labelling strategy: Engineered Ca2+ sensor biotinylates nearby proteins. Those proteins can then be stained - works for single vesicles, organelles, dendritic compartments, all the way to neuronal engrams. Both in culture and in vivo!

Molecular recording of calcium signals via calcium-dependent proximity labeling
Kim et al., Nature Chemical Biology 2024
https://doi.org/10.1038/s41589-024-01603-7

(preprint version: https://www.biorxiv.org/content/10.1101/2022.07.14.500122v2.full)

#neuroscience #MemoryEngram #neurobiology

MeredithSchmehl,
@MeredithSchmehl@mas.to avatar

I'm excited to share a new publication from my graduate work!

In this opinion piece, we describe a new idea about how the brain represents more than one object - by having neurons switch their activity over time. This new idea has implications across a wide range of other areas of neuroscience, including how parts of objects come together to form a whole, and how we select what to pay attention to in busy environments.

https://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613(24)00103-7

#Neuroscience #NeuroMastodon #CognitiveScience

moritz_negwer,
@moritz_negwer@mstdn.science avatar

LAMP1 protein-tracking with clever use of proximity labeling reveals neuron-specific Lysosomal function.

Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons
Li et al., preprint at biorxiv 2024
https://www.biorxiv.org/content/10.1101/2024.05.16.594502v1?ct=

#preprint #neuroscience #proteomics #lysosome

DharmaDog,
@DharmaDog@mastodon.social avatar


"Scientists have made 'significant' strides in the field of reading people's minds."

NDTV:
Scientists Create New Tech That Can Read People's Mind With Shocking Accuracy

"The region of the brain that Caltech team used was supramarginal gyrus - a crucial component for the understanding and processing of language."
https://www.ndtv.com/science/scientists-create-new-tech-that-can-read-peoples-mind-with-shocking-accuracy-5661141

Weanerdog,
@Weanerdog@c.im avatar

@DharmaDog

Well mathematically I'm just a conscience formed by stray atoms and none of this has ever existed.

So good luck reading that.

Also I don't language so good.

auditoryJoel,
@auditoryJoel@neuromatch.social avatar

I’m part of the #EEGManyLabs project testing the #replicability of influential #EEG studies. We are using #PredictionMarkets as a tool in this effort and you are invited to take part, especially if you have some expertise in EEG research, no matter how little. See below for details.

You may well know about the success of “prediction markets” in forecasting the likelihood of replication (e.g., Dreber et al., PNAS 2015). We are delighted to announce that we have partnered with economists who led these seminal studies to test the wisdom of the EEG community.

From today (as we near the end of recruitment for this project - please see last calls below), we are opening a survey to ask you to vote on the likelihood of some hypotheses studied in the #EEGManyLabs project. Subsequently, you will be invited to bet on the likelihood of success through a stock market platform, where you will earn real money for you or a selected charity.

The success of this effort will become clear when we complete the full project in a few years time. But the results will immediately tell us about the degree of optimism/pessimism amongst our community.

So, please share this widely and place your bets now...

How can I sign up for the prediction markets? Registrations to participate in the prediction markets are administered via the sign-up form linked below. You must have experience of working with EEG (for example, through collecting and/or analysing EEG data, which may be evidenced by having published peer-reviewed articles or preprints with EEG or equivalent experience e.g. designing, collecting and analysing data from EEG experiments).

#neuroscience #psychology #replication #replicationcrisis #reproducibility #metascience

https://pavlovug-dot-yamm-track.appspot.com/2fDq4NW3JydtlOhg09G1yGVAVSU8W-Whs6kPML9_ZfizxufZcjwEmQPWP5AnyD8NUrSZsBDvk7fYcappAg1Sgo3_tXQFMEu2Cc91Q_7ZoUrnvmZiS20DZiHsSFcGXN3Cpu_h990jl35DhtizskaAYiFIXKDiVMD0arROUO4-wXStjr4hF_n39GH14z3uQM6NK9ioOU86MruRx

jonny,
@jonny@neuromatch.social avatar

@auditoryJoel oh my god this sounds like so much fun. Is there a "neuroscientist who has read lots of EEG lit but never done an EEG experiment" tier?

albertcardona, (edited )
@albertcardona@mathstodon.xyz avatar

"A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution" by Shapson-Coe et al. 2024 (Lichtman lab).

The reconstruction at its current state is already useful and very interesting. Here is to hoping the authors will put in more time and resources to further polish it.

Paper: https://www.science.org/doi/10.1126/science.adk4858

Preprint (2021): https://www.biorxiv.org/content/10.1101/2021.05.29.446289.abstract

Browsable data: https://h01-release.storage.googleapis.com/landing.html

Viren Jain's (Google) press release: https://research.google/blog/ten-years-of-neuroscience-at-google-yields-maps-of-human-brain/

albertcardona,
@albertcardona@mathstodon.xyz avatar

A remarkable finding from Shapson-Coe et al. 2024 paper on human brain : the presence of canalized connections in the human brain cortex. Canalized in the Kauffman boolean networks sense [1], which here means: among the many synaptic inputs that any one neuron integrates, some are far stronger (by number of synapses) than the rest.

This is a pattern that we described in the larval nervous system (Ohyama et al. 2015 https://www.nature.com/articles/nature14297 ) and that has been reported as well for the mouse hippocampus (Bartol et al. 2015 https://elifesciences.org/articles/10778 ) and cerebellum (Nguyen et al. 2023 https://www.nature.com/articles/s41586-022-05471-w ).

[1] Canalisation as a term was introduced by Waddington in 1942 in the context of genetics to mean "some phenotypic traits are very robust to small perturbations" https://en.wikipedia.org/wiki/Canalisation_(genetics)

albertcardona,
@albertcardona@mathstodon.xyz avatar

"Lu.i -- A low-cost electronic neuron for education and outreach" by Stradmann et al. 2024 https://arxiv.org/abs/2404.16664

#neuromorphic #neuroscience #education

ach,

@albertcardona I was confused about the need for three separate ICs until I actually looked at the paper. Using a few op-amps is not too unreasonable. :-)

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