"Herein, we describe the clinical case of an immunosuppressed host in whom inadequate treatment resulted in highly diverse SARS-CoV-2 mutations that threatened the patient’s health due to the development of drug-resistant variants."
Animal & bacterial cells use shared mechanisms to defend against #viruses. This Primer explores a #PLOSBiology study that uses analysis of three families of immune genes to illuminate this evolutionary connection and trace the emergence of #antiviral signaling. Paper: https://plos.io/46SfBqM Primer: https://plos.io/4bwHmZt
The #evolutionary#origins of eukaryotic innate #immune systems have firmly crossed prokaryotic divide. Their study is fascinating, provides really interesting insights & avenues of future discovery
A practical plan for strengthening the incredible antiviral defenses located in your gut and resolving symptoms—from a renowned gastroenterologist and the author of Gutbliss.
Was doing some online research last night and ran across this article from 2020 talking about how spironolactone, a 50 y.o. drug used to treat hypokalemia, hypertension, and CHF targets an Epstein-Barr virus protein that is key to its replication. #EBV#antiviral
Data from a new antiviral (Xocova) shows that ppl test negative ~36 hrs faster than those who take a placebo and symptoms disappear quicker, too. Rebound appears “vanishingly rare” & some tentative evidence suggests that the drug can help protect patients from developing long COVID. Boulware says that the FDA appears to be “slow walking” the approval process. #COVID19#antiviral#medicine
🚨🚨🚨This drug is accelerating #SARSCoV2 evolution.
"Continued widespread administration of molnupiravir seems inadvisable."
Molnupiravir, an antiviral drug used to treat COVID-19, induces numerous mutations in the SARS-CoV-2 genome that can increase the rate at which the virus evolves — yielding viral variants that might survive and be passed on.
A start-up biotechnology company says it received the okay for its investigational new drug application of an anti-viral drug to treat a whole class of seasonal flu strains.
Well. I made it all the way through to the very official end of the Public Health Emergency before catching #covid myself. Been "exposed" to hundreds of cases since the start of the pandemic (always with an N95 on). So it was likely some chance hallway conversation when I wasn't being diligent. I'll never know. Luckily my symptoms are not severe.
Now starting #Paxlovid, and trying to keep the rest of the family from catching it (this is the first case in my household).
#Covid symptoms resolved fully on Paxlovid and have not (yet) rebounded. First tested negative on day 7.
my spouse tested positive this morning (and just started #Paxlovid). My isolation efforts were insufficient or too late.
kids both still testing negative and feel well.
I'd love to learn more on how oral #antiviral tx for covid may influence the immune response, especially in the mucosal compartment (knowing covid mucosal immunity is very limited and seems relatively poorly studied). Also, not directly related, but I read a study last year that covid patients with GI symptoms had better outcomes -- systemic inflammatory response seemed to be downregulated -- than patients without GI sx, and I wonder how much the compartments "communicate" igA.
The classic trilemma goes: "Fast, cheap or good, pick any two." The Moderator's Trilemma goes, "Large, diverse userbase; centralized platforms; don't anger users - pick any two." The Moderator's Trilemma is introduced in "Moderating the Fediverse: Content Moderation on Distributed Social Media," a superb paper from @arozenshtein U of Minnesota Law, forthcoming in the journal Free Speech Law, available as a prepub on SSRN:
Fediverse applications are frequently designed to be #antiviral - that is, to prevent spectacular spreads of information across the system.
It's possible - likely, even - that future Fediverse servers will be operated by commercial operators seeking to maximize attention in order to maximize revenue.
I'm spending three days #experimenting with a heavy-duty #antiviral to see if boosts my energy for the rest of the month.
The grogginess it causes is too reminiscent of my worst sick years (which makes me feel panicky).
What would help: If you would please reply with silly memes, absurd jokes, interesting stories, everyday magic, and goofiness, it would do wonders for keeping my mind off my mind.