@xtaldave@xtaldave.net
@xtaldave@xtaldave.net avatar

xtaldave

@xtaldave@xtaldave.net

Your friendly neighbourhood macromolecular crystallographer. Working on treatments for Cancer & Neurodegeneration.

Mediocre lefty bassist.
Fairphone Enjoyer.
Xennial.
Mostly in and around London, UK.

Born at 335 ppm. Go 💚 or go 🪦

May contain traces of hyperbole & sarcasm.

Alt Profile: Street art of Donald Duck, dressed as Satan
Alt Banner: A glowing blue drug molecule bound to RET kinase domain

#Science #StructuralBiology #Crystallography #Bass #Mastodog #London #nobot

This profile is from a federated server and may be incomplete. Browse more on the original instance.

xtaldave, to strucbio
@xtaldave@xtaldave.net avatar

The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA

New Human Ribosome structure dropped. Lots of new bits and pieces.

#CryoEM #StructuralBiology @strucbio
https://www.nature.com/articles/s41594-024-01274-x

xtaldave, to strucbio
@xtaldave@xtaldave.net avatar

Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction | bioRxiv

For fans of fragment based screening

#Crystallography #StructuralBiolgy @strucbio

https://www.biorxiv.org/content/10.1101/2024.06.03.596235v1?rss=1

xtaldave, to random
@xtaldave@xtaldave.net avatar

Cuuuuuuuuuuuuuunts

Let's be clear, there is no confusion, just bigotry. They want to legally enshrine bigotry.

BBC News - Tories pledge to tackle 'confusion' over legal definition of sex
https://www.bbc.com/news/articles/c0kkvkkejgno

xtaldave, to random
@xtaldave@xtaldave.net avatar

Who knew Varadkar was such an absolute UNIT?

xtaldave, to random
@xtaldave@xtaldave.net avatar

If Labour wins a 1945-style landslide, it will have no excuse for playing it safe | Larry Elliott | The Guardian

Yes yes and yes. A massive mandate requires a bold program. PR. Renationalisation of key infrastructure. Wealth taxes. All that good shit.

https://www.theguardian.com/commentisfree/article/2024/may/30/labour-1945-tories-fiscal-rules-election

xtaldave,
@xtaldave@xtaldave.net avatar

@zleap I hope they are bold enough to make some important and long lasting changes

xtaldave, to random
@xtaldave@xtaldave.net avatar

"UK is 'running out of ghosts' as old spirits dying off, paranormal expert says"

xtaldave, to random
@xtaldave@xtaldave.net avatar

Labour's Rachel Reeves rules out increasing income tax or NI

What is the actual point of this? We know the country is on its knees. We need to invest. I'd gladly pay more taxes to have functional NHS, roads, schools, etc.

https://www.bbc.co.uk/news/uk-politics-69063581

xtaldave, to random
@xtaldave@xtaldave.net avatar

Mechanical-Armed Grimes Flees Elon Musk Compound With Five Wives In Stolen Cybertruck

"...escape to the idyllic, faraway land of Grimes’ childhood, which she simply called “Canada.”"

https://www.theonion.com/mechanical-armed-grimes-flees-elon-musk-compound-with-f-1851488909

xtaldave, to random
@xtaldave@xtaldave.net avatar

Happy Towel Day, Hoopy Froods!

Flashing Don't Panic GIF

xtaldave, to random
@xtaldave@xtaldave.net avatar

Oh bollocks.

Microplastics found in every human testicle in study | Plastics | The Guardian

https://www.theguardian.com/environment/article/2024/may/20/microplastics-human-testicles-study-sperm-counts

xtaldave, to random
@xtaldave@xtaldave.net avatar

Putin denies plans to capture Ukrainian city of Kharkiv

So he definitely does then. 👀

https://www.channel4.com/news/putin-denies-plans-to-capture-ukrainian-city-of-kharkiv

xtaldave, to bass
@xtaldave@xtaldave.net avatar

This bass has an Ass. (It's a Caracal 034)
#Bass

xtaldave, to strucbio
@xtaldave@xtaldave.net avatar

:geordi_no: Alphafold3. Not FOSS. Not FAIR. Public version has important features redacted.

:geordi_ye: OpenFold: retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization | Nature Methods

Faster. FOSS. FAIR.

@strucbio

https://www.nature.com/articles/s41592-024-02272-z

xtaldave, to structbio
@xtaldave@xtaldave.net avatar

The AlphaFold3 Transparency and Reproducibility letter and signatories zenodo page

@structbio
https://zenodo.org/records/11192369

xtaldave, to strucbio
@xtaldave@xtaldave.net avatar

Open letter to Nature editors complaining about the lack of code availability for AF3 (Publishing code is normally a prerequisite for publishing in Nature)

(Yes, I am fully aware of the irony of using a Google form to do this - not my idea, just sharing.)

@strucbio

https://docs.google.com/forms/d/e/1FAIpQLSf6ioZPbxiDZy5h4qxo-bHa0XOTOxEYHObht0SX8EgwfPHY_g/viewform

xtaldave,
@xtaldave@xtaldave.net avatar

@markus They very much did

xtaldave,
@xtaldave@xtaldave.net avatar

@markus The worst part is that Nature let them get away with this, but the rest of us plebs are always required to show our working. Can't have a two tier system.

xtaldave,
@xtaldave@xtaldave.net avatar

@graemewinter @markus yup - it's only available by server with a Google login, 10 shots a day, limited functionality. It's not great.

xtaldave, to Georgia
@xtaldave@xtaldave.net avatar

She's singing about the sun and fire whilst a geomagnetic storm hits? Coincidence?

xtaldave, to Eurovision
@xtaldave@xtaldave.net avatar

Gotta flog that merch #Eurovision.

xtaldave,
@xtaldave@xtaldave.net avatar

@DJDarren white ford transit in the parking lot.

xtaldave, to Eurovision
@xtaldave@xtaldave.net avatar
xtaldave, to Eurovision
@xtaldave@xtaldave.net avatar

The EBU is currently in a crisis meeting, according to information on SVT.

https://www.svt.se/kultur/senaste-nytt-om-eurovision-song-contest-2024

xtaldave, to random
@xtaldave@xtaldave.net avatar

BBC News: Sunak says it'll take time for people to feel better - BBC News

Yup. After the election when your fucking arse has been handed to you, and you've fucked off to silicon valley you rat-faced cunt.
https://www.bbc.co.uk/news/articles/cmm3gzz1dj3o

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