Honored to keep company with #neurologist, #DanielGibbs's #book about his own experience of #dementia. The tattoo in the title is the #brain bleed (aka #ARIA) that occurred while in #clinicaltrials related to anti-#amyloid drugs. He has no regrets & would do it all over again if it might advance brain science & help in the effort to #ENDALZ.
If you have read either my #memoir or his, please consider reviewing them on #amazon. In different ways, we both aim to inform readers & undercut #stigma.
What is known as the #prodromal phase, the years when #Alzheimer's is attacking the brain but the clinical presentations may not yet be apparent. "One early hallmark is that sticky protein called beta-amyloid, which over time builds up into brain-clogging #plaques. #Amyloid alone isn’t enough to damage memory — plenty of healthy people’s brains harbor a lot of plaque. An abnormal #tau protein that forms neuron-killing tangles is one of several co-conspirators."
Why diagnose someone with #Alzheimer's who has no memory issues but a build-up of #tau and/or #amyloid protein? Here's why. In a Nov, call with Wall St. analysts, Masoud Toloue, the chief executive at Quanterix, pointed out that the company’s blood test for tau — p-Tau 217 — had been recommended by the panel for diagnosing the disease. “We believe we’re in a strong position to capitalize on these opportunities,” Toloue said. "Opportunities"? Sickening.
Since language acquisition and fluency is on my #brain (all of the videos of #Trump's attempts at speech are firing lots of my own cylinders!), here is another image of the brain from #FindingTheRightWords. Thank you to the amazing #CarolinePrioleau of #UCSF for this beautiful and helpful drawing.
@wlf_warren. You are welcome. You can access them yourself -- there is one of misfolded #proteins; another with #tau and #amyloid stains -- (and some other photos from the wayback machine) at the book website. The book itself has the images in black and white, but the website has them in color. Just click this link and then go to the book link and then click the figures link! https://weinsteinandmiller.com
A new crowdsourced competition seeks more robust early indicators of Alzheimer's disease and related dementias using analytics powered by artificial intelligence.
Better to go after the early indicators of the clinically important issue, #dementia. Since our definition of “ #Alzheimers“ is fatally flawed with circular logic (thanks Jack et al.) we will only end up with early indicators of #amyloid build up. We’ve got to do better if we hope to make real progress.
It describes the structure of #amyloid fibrils formed by the mutant protein behind Huntington’s disease. We teamed up with the group of Markus Miettinen at the University of Bergen (prev. MPI colloids at Potsdam @maxplanckgesellschaft