The authors argue that protected & #conservation areas that meet all 4 criteria—which they name #Nature's #Strongholds"—will be disproportionately important for biodiversity conservation.
How do we process images with high vs low #memorability? @Blahner@Yalda_Mhz &co show that only images with high memorability scores undergo extended processing late in time throughout the ventral visual stream, including early #VisualCortex#PLOSBiologyhttps://plos.io/4cDqn8u
MYCN drives #neuroblastoma by activating ribo biogenesis & protein synth genes, but repressing neuronal differentiation genes. @theNCI study shows that #MYCN cooperates with the HMT G9a & WDR5 adaptor to orchestrate global gene transcription #PLOSBiologyhttps://plos.io/4amRZ03
Potassium channels regulate the scale of #fish fins, but how? This study shows that the scale of #zebrafish embryonic pectoral fins is determined by the regulation of intracellular K+ by retinoic acid via Rcan2 & #PotassiumChannel Kcnk5b #PLOSBiologyhttps://plos.io/3IOCu53
Stem cell microenvironment: Inter-niche signaling in #Drosophila ovary reveals a mechanism involving miR124 & EGFR that regulates #StemCell function & sharpens the spatial distinction between self-renewal & differentiation microenvironments #PLOSBiologyhttps://plos.io/3TM3Ajf
How does E3 #ubiquitin ligase RFDW3 regulate #ReplicationFork progression & stability? This study reveals that RFWD3 ubiquitylates SMARCAL1, disengaging it from RPA, limiting its activity at stalled forks & preventing fork collapse #PLOSBiologyhttps://plos.io/3TsE6q5
#Galactose is an important sugar that can fuel glycolysis, but tracking its metabolic dynamics in vivo is challenging. @Yoo_Lab_RIKEN describe #GALDAR, a genetically encoded sensor to measure intracellular galactose dynamics in flies #PLOSBiologyhttps://plos.io/3Vx63iO
Some drugs increase the #mutation rate of their target #pathogen, raising the concerns they might increase the pathogen’s rate of adaptation. This #PLOSBiology Perspective proposes a four-step process to evaluate the evolutionary safety of new treatments.
The envelope protein is highly conserved among human #coronaviruses, suggesting it could be a good drug target. This #PLOSBiology study identifies iPep-SARS2-E and shows that it inhibits #SARSCoV2 infection in lung organoids and in mice.
Mismatches can induce unwanted cleavage events and off-target effects in CRISPR-Cas12a-based #GeneEditing. This #PLOSBiology study describes a high-fidelity AsCas12a variant with improved targeting specificity.
This #PLOSBiology study in E. coli reveals a novel role for polyphosphate kinase in the expression of enzymes that promote resistance to the last-resort #antibiotic polymyxin.
The papillae of Ciona, a marine, non-vertebrate #tunicate, have many functions crucial for their biphasic lifestyle. This #PLOSBiology study describes different papillae cell types and how they contribute to #development of the larvae.
The design and fabrication of customized #microwells and #microfluidic chips is often challenging. This #PLOSBiology study describes a pipeline for resin-based 3D printed constructs and provides a variety of applications in biological #experiments.
PEX5 transports new proteins from cytosol to #peroxisome, where it is reversibly mono-Ub'ed at Cys11 for return to the #cytosol; longer #ubiquitin chains attached to Cys11 are rapidly removed by the enzyme E2D3, ensuring correct function #PLOSBiologyhttps://plos.io/4a9gWf4
Selective attention enables separation of overlapping speech in noisy environments. This study shows that #attention triggers bidirectional informational flow from #sensory regions to regions associated with semantic, syntactic & executive functions during active processing of #CocktailParty speech #PLOSBiologyhttps://plos.io/3uZKBse