@lupomancer@dragonarchitect I'm not sure of a good way off-hand. I currently mostly just kinda adjust my thermostat when I need to, I haven't written any HA automations to handle adjusting it but I've got sensors in every room. Mind I'm away right now so it's giving the away setpoint up top there.
I know @mathias has an ecobee with a single satellite sensor for it, but I don't think does any thermostat comfort adjustments based on any other sensors yet (though that's probably partly because he only recently got sensors)
I really should see about setting something up that factors humidity in. The hard part is just making something that won't ever get in my way.