Omega_Scribet,
@Omega_Scribet@mastodon.social avatar

The University of Chicago:

'Inverse vaccine” shows potential to treat multiple sclerosis and other autoimmune diseases'

"has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis and type 1 diabetes — all without shutting down the rest of the immune system."
1/n

#autoimmunedisease
#diabetes1
#type1diabetes
#multiplesclerosis
#celiacdisease

Omega_Scribet,
@Omega_Scribet@mastodon.social avatar

"The inverse vaccine, described in Nature Biomedical Engineering, takes advantage of how the liver naturally marks molecules from broken-down cells with “do not attack” flags to prevent autoimmune reactions to cells that die by natural processes."

See my 4th post in this thread to go directly to the article in Nature Biomedical Engineering.

2/4

Omega_Scribet,
@Omega_Scribet@mastodon.social avatar

"Initial phase I safety trials of a glycosylation-modified antigen therapy based on this preclinical work have already been carried out in people with celiac disease, an autoimmune disease that is associated with eating wheat, barley and rye, and phase I safety trials are under way in multiple sclerosis. Those trials are conducted by the pharmaceutical company Anokion SA"

https://pme.uchicago.edu/news/inverse-vaccine-shows-potential-treat-multiple-sclerosis-and-other-autoimmune-diseases

3/4

Omega_Scribet,
@Omega_Scribet@mastodon.social avatar

Nature Biomedical Engineering:

'Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses'

"Our findings show that pGal–antigen therapy invokes mechanisms of immune tolerance to resolve antigen-specific inflammatory T-cell responses and suggest that the therapy may be applicable across autoimmune diseases."

https://www.nature.com/articles/s41551-023-01086-2

4/4

johnefrancis,
@johnefrancis@mastodon.social avatar
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