Global research-and-development (R&D) investment works out to $1,286 per capita per year in high-income countries and just $42 in low and middle income countries. https://www.nature.com/articles/d41586-023-02998-4
The article focuses on "benevolent #patent extension" as a partial remedy. "An inventor who applies to patent a ‘benevolent discovery’ — one that targets LMICs’ needs — [can] offset the R&D costs by extending another patent, for a ‘non-essential’ product."