Yes, definitely. Why you are doing it makes all the difference.
There is - in my experience - a good deal of how you - and the organisation in general - do it too, and that accounts for much of the cultural difference. Charities tend to treat staff (and volunteers - since so many depend on vols) as people rather that resources much more, although there is also a tendency for the cause to outweigh everything, which can lead to staff, particularly, being expected to commit totally around the clock, and sidelined if they don’t. I have only encountered a few organisations that do this to a problematic extent really though.