@jake4480
Some games can be played from an USB drive, but there are plenty that will have problems. Some won't even start up it crashes immediately, others have problems with the FMV (full-motion video) playback being to choppy ruining the experience of playing the games in the first place.
Yeah PS2 games can get really big especially if there were release as multi disc games and even some of the single disc games can go as high as 8GB, like for example Yakuza 2.