TheImpressiveX, 
I’m at a loss for words on this one.
FiskFisk33, That’s not a pipe!
ApostleO, Is this lasagna?
fushuan, Lossagna!
nailbar, Oh damn!
Ferrous, That cat sure does love lasagna.
Socsa, All my life has been preparing for this moment.
Jackcooper, Is this win?
ImplyingImplications, Ceci n’est pas perdu
grrgyle, Now this is the kind of thing we should be beaming into space
Apepollo11, (edited ) Garfield and Jon at hospital. Garfield, his pipe lit.
DontTreadOnBigfoot, 
Garfield, when Otis fell.
SidewaysHighways, Jon, his eyes red
gibmiser,
SomeAmateur, Teachers explaining short stories be like
jballs, 
Wtf this is AN HOUR LONG?!
GuerillaGorillas, It’s worth every second.
classic, It so damn perfect. It just gets it
General_Shenanigans, In a single shot, too.
Kichae, Don’t tell me you Lost it
son_named_bort, Now where could Loss be?
Iheartcheese, 
He smokes because of his daddy issues
Apepollo11, Is this pipe?
Hubi, 
Ceci n’est pas une pipe
fristislurper, 
Ceci n’est pas perdu
Akasazh, 
Rene?
BackOnMyBS, 
that is not a pipe
psmgx, Meme-ception
QualifiedKitten, Could you maybe please explain for those of us who only get half (or none) of it?
SpikesOtherDog, Loss
QualifiedKitten, That's the half I picked up on, but based on the other comments, it seems like there's something else that I'm missing.
davidgro, Well, there’s this. Source: The YouTube video in another comment here.
SatansMaggotyCumFart,
Lumun, (edited ) 
The pipe comic with Garfield was also likely referencing a famous Magritte painting.
The painting is a kind of play on self-reference
Meme-ception for sure
Ephera, It’s an internet meme culture thing: en.wikipedia.org/wiki/Loss_(comic)
Particularly, the section “Legacy as an internet meme” is relevant.
whaleross, 
It is, isn’t it
FreshLight, Yes.
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