I did in my late 20s after working in IT. I didn’t know what I wanted and wasn’t planning on non-profit or anything as such, but jumped ship, did a range of random things before spending some time volunteering (at something that was not in any way IT related)- which was the critical thing. That put me in a spot to A) show some commitment and B) get some training as it was offered. A paid post followed in due course after that.
That is a very simplified version, but volunteering was definitely the critical element for me.
Since then, I met plenty of other people who made the jump. Some simply moved with their existing skills to an equivalent role in a charity - and there are plenty that need project management skills - whilst others have taken the same route as me and spent some time volunteering.
Volunteering means you don’t get paid for some time, of course, so you have to either live off savings and/or find a live-in role and/or work part-time or something and you probably need to downsize one way or another, but people find a way and make it work.
Of course once you are in a role with your chosen cause, that doesn’t necessarily mean that you will be away from being overworked, stressed and given more and more responsibility. It is a trope that working for a charity means that you don’t do it for the money and you work waaay longer than the official hours say.
Certainly my role at the moment, with a large charity, is the most demanding I have ever had and there is basically nothing left at the end of the month for savings: I am just keeping afloat. For all that though, there is no way at all that I would go back to a for-profit role, and I have never looked back for a moment. The culture is totally different and leagues better.