NicoleCRust,
@NicoleCRust@neuromatch.social avatar

Pointers to examples of using complex systems approaches to develop therapeutic interventions?

I'm excited by the type of approach presented in these three papers, which I would summarize as:

  1. Model a complex system w/ attractor states (like a genetic network) with a lot of detail
  2. Reduce the model's complexity to something more understandable
  3. Therapy = control. Determine the intervention that will perturb the system from the unhealthy to healthy attractor state.

https://www.pnas.org/doi/full/10.1073/pnas.0806447105
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002267
https://www.nature.com/articles/ncomms11323

Do you know of any examples of this type of approach? Especially ones that led to a new type of therapy that is either approved, in clinical trials or just thought of? Maybe cancer?

Rhyothemis,

@NicoleCRust

This popped up in my YT feed last night - not sure if it is what you are looking for

Tumor Immunotherapy Discovery Engine (TIDE) | Broad Institute
https://youtu.be/IoRvY4zleKk?si=nLWoHnmn8Jz_3BaW

teixi,
@teixi@mastodon.social avatar

@NicoleCRust

Have some links for #complexsystems for #cogsci #neurotheory #brainimaging etc.

Albeit then also going forward to therapeutic interventions?
Quite rare, difficult to qualify & interpret!

Just learned:
''Sham stimulation'
as placebo effect equivalent —inactive, brief, or weak form of directed brainwaves— for:
#tDCS Transcranial Direct Current Stimulation
#tACS Transcranial Alternating Current Stimulation
#tRNS Transcranial Random Noise Stimulation

check https://www.neuroelectrics.com/wiki/images/4/4d/HIVE-D1.1_State-of-the-art-V1.3withcovers-small.pdf

p_r_francois,

@NicoleCRust our next paper following up on the one below addresses some of this, stay tuned (or come to our talks :) ) https://www.science.org/doi/10.1126/science.abl5311?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

NicoleCRust,
@NicoleCRust@neuromatch.social avatar

@p_r_francois
Great! Please keep us posted.

acm_redfox,
@acm_redfox@jawns.club avatar

@NicoleCRust cool idea!

DrYohanJohn,

@NicoleCRust

I sometimes wonder if existing therapies can best be framed in dynamical systems terms. Take ECT. Assuming that it sometimes works, perhaps it is primarily a perturbation that bumps a system into a nearby attractor?

Another example: a neuroscientist and Buddhist meditation practitioner named Patricia Sharp once described meditation as a way of destroying attractors that correspond to bad repetitive thoughts/behaviors, and then creating new ones.

https://philpapers.org/rec/SHABEA

tdverstynen,
@tdverstynen@neuromatch.social avatar

@DrYohanJohn @NicoleCRust

Completely anecdotal and subjective, but this is how I would describe my experience after spending time in sensory deprivation tanks (which I do 1-2x month). There's a point during the experience where my mind just goes completely quiet. No more wondering thoughts or sense of self. I call it "annihilation" (for lack of a better word). Afterwards, there is a feeling of calm that persists for 1-2 days and my reactions to things feel just different, as if I've gone through a neural/mental reset. It's like I'm a slightly new person after each float in the tank.

DrYohanJohn,

@tdverstynen @NicoleCRust

Nice! I've only done a float once, ages ago. I should try it again. I really loved it.

tdverstynen,
@tdverstynen@neuromatch.social avatar

@DrYohanJohn @NicoleCRust

It takes a while to get used to the full sensory deprivation experience, but I now love it as an integral part of my mental health maintenance.

skarthik,

@tdverstynen @DrYohanJohn @NicoleCRust

We were talking about sensory deprivation tanks in our lab meeting on Wednesday (I think the discussion started with anechoic chambers). I have one just half a mile from where I live, never really been there though. Maybe I should.

@NicoleCRust I think the new push towards treatments with psychedelics will be interesting and in my opinion adheres to all three of your points.

Some cancer patients have preferred psychedelics as the best course for their pain relief as well during chemo.

NicoleCRust,
@NicoleCRust@neuromatch.social avatar
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